Cell 116: 457-466 (2004), 17) Haramis, A.P., Begthel, H., van den Born, M., van Es, J., Jonkheer, S., Offerhaus, G.J., Clevers, H. De novo crypt formation and Juvenile Polyposis upon BMP inhibition. Science 275: 1787-1790 (1997), 7) van de Wetering, M., Cavallo, R., Dooijes, D., van Beest, M., van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., Peifer, M., Mortin, M., and Clevers, H. Armadillo co-activates transcription driven by the product of the Drosophila segment polarity gene dTCF. A breeding ground for spin off companies. The Hubrecht Institute has an impressive track record in delivering the scientific leaders of the future. Science 285: 1923-1926 (1999), 11) Korswagen, R., Herman, M. and Clevers, H. Separate beta-catenins mediate Wnt signaling and cadherin adhesion in C. elegans. Hubrecht Institute. Publications. Maurice, M.M. The impact score places the Hubrecht also as one of the premier biology research institutes world-wide. Cell 161: 933-945 (2015), 49) Drost, J., van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A.,Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H. Sequential cancer mutations in cultured human intestinal stem cells. Articles Cited by. Sort by citations Sort by year Sort by title. The Hubrecht Institute is one of the fifteen outstanding national research institutes of the Royal Netherlands Academy of Arts and Sciences (KNAW). The institute encompasses 23 research groups that perform fundamental, multidisciplinary research on healthy and diseased cells, tissues and organisms. The Hubrecht is a highly dynamic, diverse and young institute where the average age of the researchers is around 30 and more than 30 different nationalities are represented. And Clevers, H. Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H . This research leads to innovation in treatment of cancer, diabetes and cardiovascular diseases among others. From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. and Clevers, H. van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., ... Garnett, M.J., Clevers, H. Boj, S.F., Hwang, C.I., Baker, L.A., Chio, I.I., Engle, D.D., ..., Clevers, H, Tuveson, D.A. 2005 Katharine Berkan Judd Award, New York and Clevers, H.C. van de Wetering, M., Oosterwegel, M., Dooijes, D., and Clevers, H.C. Hans Clevers is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. Science 337: 730-735 (2012), 37) van Es, J.H., Sato, T., van de Wetering, M., Lyubimova, A., Yee Nee, A.N., Gregorieff, A., Sasaki, N., Zeinstra, L., van den Born, M., Korving, J., Martens, A.C., Barker, N., van Oudenaarden, A., Clevers, H. Dll1(+) secretory progenitor cells revert to stem cells upon crypt damage. Cell 149: 1245-1256 (2012), 35) Koo, B-K., Spit, M. Jordens, I., Low, T.Y., Stange, D.E., van de Wetering, M., van Es, J.H., Mohammed, S., Heck, A.J.R., Maurice, M.M. A variety of biological processes are being studied, mainly concerning embryonic development and development and homeostasis of organs. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. In 1991, we reported the cloning of a T cell specific transcription factor that we termed TCF1 (1). Stem cells and organoids Hans Clevers became famous with his stem-cell research into healthy and sick intestines. These organoids recapitulate many aspects of their tissue of origin and allow the study of a multitude of physiological and pathological processes. UMC Utrecht This is reflected by a citation impact score of around 3.0, putting the Hubrecht at the top of the list of all institutes and universities in the Netherlands. 2002 – 2020 Professor in Molecular Genetics at University Medical Center Utrecht Cell 151: 1595-1607 (2012), 39) Huch, M., Dorrell, C., Boj, S.F., van Es, J.H., van de Wetering, M., Li, V.S.W., Hamer, K., Sasaki, N., Finegold, M.J., Haft, A., Grompe, M., Clevers, H. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. In the absence of Wnt signaling, we found that Tcf factors associate with proteins of the Groucho family of transcriptional repressors to repress target gene transcription (9). Nature 469: 415-418 (2011). Cited by. People are our most valuable asset and we appreciate every employee for their contribution to the success of the institute. 2019 Citation Laureate, Web of Science Group, 2008 – 2015 Louis Jeantet Prize, Geneva Publications 19. 9 Oncode Institute, Utrecht, the Netherlands. Forskolin opens the CFTR channel, resulting in rapid swelling of normal organoids. Hans Clevers is professor of Molecular Genetics at Utrecht University and the UMC Utrecht, Principal Investigator at the Hubrecht Institute (KNAW) and the Princess Máxima Center for Pediatric Oncology and Oncode Investigator. 2016 The Academy Professor Prize of the Royal Netherlands Academy Prof. Dr. James Sharpe, EMBL, Barcelona In 2007 the name was changed from Hubrecht Laboratory to Hubrecht Institute. The Hubrecht Institute provides an infrastructure that embeds the group in an efficient facility support so that group leaders can focus on the research. European Molecular Biology Laboratory (EMBL) Two other Wnt target genes, RNF43 and ZNRF3, encode stem cell-specific E3 ligases that downregulate Wnt receptors. The tumor suppressor protein APC forms the core of a cytoplasmic complex which binds ß-catenin and targets it for degradation in the proteasome. From 2002-2012 he was director of the Hubrecht Institute in Utrecht and from 2012-2015 he was President of the Royal … Technologies including organoid technology, single-cell sequencing, and non-invasive prenatal testing were all developed at the Hubrecht Institute and are now implemented with our help at many other institutes and universities in the Netherlands. They also represent the cells-of-origin of adenomas in the gut (25) and within adenomas Lgr5 stem cells act as adenoma stem cells (36). 2020 – present Member of the Board of Genentech, South San Francisco As a patient-centered organization, its 11,000 employees are dedicated to prevent disease, improve healthcare, develop new treatment methods and refine existing ones, with quality and patient safety as cornerstones. Since 2008, the Hubrecht Institute is affiliated with University Medical Center Utrecht (UMC Utrecht), which belongs to the largest public healthcare institutions in the Netherlands and is an internationally leading healthcare provider, medical school and research institute that is exciting for its people, attractive to talent and embodies a culture of teamwork, innovation, sustainability and a competitive spirit. 2017 – 2018 President of the International Society for Stem Cell Research (ISSCR) Electronic address: h.clevers@hubrecht.eu. The Hubrecht Institute is one of the fifteen outstanding national research institutes of the Royal Netherlands Academy of Arts and Sciences (KNAW). Hubrecht Institute - Utrecht. 10 Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. 2009 The Queen Wilhelmina Dutch Cancer Society Award, Amsterdam floxed), Reporter) Gt(ROSA)26Sor: gene … ↵ † Present address: … The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on the Utrecht Science Park. 2006 – 2008 President of the International Society of Differentiation (ISD) Cell 160: 324-338 (2015), 48) van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., McLaren-Douglas, A., Blokker, J., Jaksani, S., Bartfeld, S., Volckman, R., van Sluis, P., Li, V.S.W., Seepo, S., Sekhar Pedamallu, C., Cibulskis, C., Carter, S.L., McKenna, A., Lawrence, M.S., Lichtenstein, L., Stewart, C., Koster, J., Versteeg, R., van Oudenaarden, A., Saez-Rodriguez, J., Vries, R.G.J., Getz, G., Wessels, L., Stratton, M.R., McDermott, U., Meyerson, M., Garnett, M.J., Clevers, H. Prospective derivation of a ‘Living Organoid Biobank’ of colorectal cancer patients. Oncode Institute All of these PhD students are affiliated with the Cancer, Stem Cells and Developmental Biology (CS&D) program of the Graduate School of Life Sciences (GSLS). They serve in a negative feedback loop to control the size of the stem cell zone (35). The related Lgr6 marks multipotent skin stem cells (29). and Clevers, H. Van de Wetering, M., Cavallo, R., Dooijes, D., Van Beest, M., Van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., Peifer, M., Mortin, M., and Clevers, H. Morin, P.J., Sparks, A., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. Korinek, V, Barker, N., Morin, P.J., van Wichen, D., de Weger, R., Kinzler, K.W., Vogelstein, B., and Clevers, H. Molenaar, M., Van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O. Research groups. Oncode Institute is a virtual, independent research institute dedicated to outsmarting cancer and impacting lives. During the last five years, the Hubrecht Institute has been very successful in attracting young talented group leaders who started a tenure track at our institute. On the shoulders of Hubrecht: From embryos to stem cells. In this video, Hans Clevers summarizes the use of organdies in cancer research. Research; Strategy; Organization; Location; Our partners; History; Open access; Working at the Hubrecht Institute; Contact. Prof. Dr. Alfonso Martinez Arias, University of Cambridge, Cambridge Science 340: 1190-1194 (2013), 41) Clevers, H. The intestinal crypt, a prototype stem cell compartment. 2016 – present Member of the Scientific Advisory Board of Decibel Therapeutics, Boston Nature 449: 1003-1007 (2007), 24) Jaks, V., Barker, N, Kasper, M., van Es, J.H., Snippert, H.J., Clevers, H., Toftgård, R. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on Utrecht Science Park. On average, one group leader annually moves on to a new position outside the Institute. Between 2002 and 2012 he served as Director of the Hubrecht Institute for Stem Cell Research. 8 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, the Netherlands. Nature Genetics 40: 1291-1299 (2008), 25) Barker, N., Ridgway, R.A., van Es, J.H., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A.R., Sansom, O.J., Clevers, H. Crypt Stem Cells as the Cells-of-Origin of Intestinal Cancer. 2004 Louis-Jeantet Prize for Medicine, Geneva, Switzerland 2005 The French honor of “Chevalier de la Legion d’Honneur” To this end, we founded the non-for-profit HUB foundation which currently builds a biobank of all 1500 Dutch CF patients funded by our national insurance companies. The team in the research group of Hans Clevers at the Hubrecht Institute overcame these issues, the rarity of enteroendocrine cells and the differences between mice and humans, in a creative way. Tumour suppressor RNF43 is a stem cell E3 ligase that induces endocytosis of Wnt receptors. 2016 Member of the Academie des Sciences de I’Institut de France 2011 Kolff prize, Amsterdam Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. 2012 – 2015 Member of the Board of the American Association of Cancer Research 2014 National Icon of the Netherlands Wnt signaling intimately interacts with the BMP and Notch cascades to drive proliferation and inhibit differentiation in intestinal crypts and adenomas (17, 20). Finally, organoids (as first described by Sasai for pluripotent stem cells and by us for adult stem cells) are rapidly gaining ground as research tools in a wide range of scientific disciplies including basic developmetal and cell biology, infectiology, toxicology and research on hereditary diseases and cancer. Nature 457: 608-611 (2009), 26) van der Flier, L.G., van Gijn, M.E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D.E., Begthel, H., van den Born, M., Guryev, V., Oving, I., van Es, J.H., Barker, N., Peters, P.J., van de Wetering, M. and Clevers, H. Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate. 3 Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. 11 Oncode Institute, Hubrecht Institute-KNAW and UMC Utrecht, Utrecht, The Netherlands h.clevers@hubrecht.eu. Cell 165:1586-1597 (2016), 52) Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J.E., van Wezel, T., Nik-Zainal, S., Kuiper, R.P., Cuppen, E., and Clevers, H. Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. The Hubrecht Institute is part of the Royal Netherlands Academy of Arts and Sciences (KNAW) and has a special partnership with the UMC Utrecht, Utrecht University, Princess Máxima Center for pediatric oncology, the European Molecular Biology Laboratory (EMBL) and Oncode Institute. Ushering in a new era of personalised medicine and drug development, Dutch molecular geneticist Hans Clevers and teams at the Hubrecht Institute and the University Medical Center (UMC) in Utrecht pioneered so-called "organoids". Dr. Clevers received his M.D. As such, they can attend the complete range of courses organized by the PhD Course Center. Princess Máxima Center for pediatric oncology (PMC) 10 Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. 2012 – 2015 President of the Royal Netherlands Academy of Sciences (KNAW), Amsterdam 1) van de Wetering, M., Oosterwegel, M., Dooijes, D., and Clevers, H.C. 31) Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, Van Houdt WJ, Pronk A, Van Gorp J, Siersema PD, Clevers H. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium. Read More + Genetic overview. 2002 – present Principal Investigator of a research group of ~40 scientists at Hubrecht Institute, Utrecht From Utrecht Central Station, it takes only 30 min to get to Amsterdam airport, Schiphol, an international hub for most major airlines. The Princess Máxima Center has open her own new hospital and research building at the Utrecht Science Park in May 2018. Contact. Developmental Biology and Stem Cell Research Cell 159:163-175 (2014), 46) Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, J., van de Wetering, M., Sasaki, N., Boers, S., Kemperman, H., de Jonge, J. IJzermans, J., Niewenhuis, E., Hoekstra, R., Strom, S., Vries, R., van der Laan, L., Cuppen, E., Clevers, H. Long-term culture of genome-stable bipotent stem cells from adult human liver. 32) Snippert, J., van der Flier, L.G., Sato, T., van Es, J.H., van den Born, M., Kroon-Veenboer, C., Barker, N.,Klein, A.M., van Rheenen, J. Benjamin D. Simons, B.D. In 2016, the Hubrecht Institute celebrated its 100th anniversary. 2019 Honorary Fellow of the Royal Society of Edinburgh (UK) 2020 – present University Professor at University Utrecht, 2000 Catharijne prize for medical research 11 Oncode Institute, Hubrecht Institute-KNAW and UMC Utrecht, Utrecht, The Netherlands h.clevers@hubrecht.eu. Cell 103: 311-320 (2000), 13) van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A-P., Tjon-Pon-Fong, M., Moerer, P., van den Born, M., Soete, G., Pals, S., Eilers, M., Medema, R., Clevers, H. The beta catenin/TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. The Tcf4-driven target gene program in colorectal cancer cells is the malignant counterpart of a physiological gene program in selfrenewing crypts (13, 14, 21). 19. 3 Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands. Research at the Hubrecht Institute is diverse and covers many aspects of developmental and stem cell biology including signaling in stem cells and early development, cardiac development, regeneration, epigenetics, genome architecture, cell cycle control, DNA repair, gene expression dynamics and quantitative biology of gene expression. The Hubrecht Institute and PMC collaborate, especially using tumor organoids, single cell sequencing and intravital imaging of tumors. View ORCID Profile Hans Clevers, View ORCID Profile Alexander van Oudenaarden * Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands. 2018 Großes Verdienstkreuz mit Stern, Germany Cell 175:1591-1606 (2018), 56) Gehart, H., van Es, J., Hamer, K., Beumer, J., Kretzschmar, K., Dekkers, J.F., Rios, A., and Clevers, H. Identification of enteroendocrine regulators by real-time single-cell differentiation mapping The Hubrecht Institute is a lively, international research community that is supported by high quality services. h.clevers@hubrecht.eu. Cell 86: 391-399 (1996), 5) Korinek, V, Barker, N., Morin, P.J., van Wichen, D., de Weger, R., Kinzler, K.W., Vogelstein, B., and Clevers, H. Constitutive Transcriptional Activation by a beta-catenin-Tcf complex in APC-/- Colon Carcinoma. For example, during the last year more than half of the top publications from the Hubrecht Institute involved more than two Hubrecht groups, demonstrating the collaborative spirit.
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